Classify and route cold email replies using Claude and Instantly.ai

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Built by Akshay Chug Akshay Chug
Created on June 05, 2026

Description

Overview :

Automatically reads every reply to your cold email campaigns in Instantly.ai, uses Claude AI to understand the intent, and takes the right action . No need ofmanual inbox checking needed.

How it works :

A lead replies to your cold email in Instantly.ai , this workflow starts automatically.
Claude AI reads the reply and labels it: Interested, Not Now, Unsubscribe, or Referral.
Each label triggers a different action calendar email, 30-day follow-up, opt-out removal, or referral ask.
Every reply gets logged to a Google Sheet automatically.

Setup steps :

Instantly webhook — In Instantly → Settings → Webhooks, add a new webhook. Paste the URL from the Receive Instantly Reply node and set the trigger to Reply Received.
Claude AI — Click the Claude Haiku node, add your Anthropic API key from console.anthropic.com. Costs less than $0.01 per reply.
Google Sheets — Create a sheet with these column headers: Timestamp | First Name | Last Name | Email | Company | Reply | Classification | Campaign. Connect your Google account in all four Log to Sheets nodes.
Gmail — Connect your Gmail in Send Calendar Link and Send Referral Reply. Replace {{CALENDAR_LINK}} with your booking link.
Slack (optional) — Connect Slack in Notify Slack - Hot Lead and pick a channel. Don’t use Slack? Right-click the node → Disable.
Instantly re-sequence — In Re-add to Instantly Sequence, add your Instantly API key and replace {{SEQUENCE_ID}} with your follow-up sequence ID.
Activate the workflow and send a test reply to confirm everything works.

Nodes Used (6)

Anthropic Chat Model
@n8n/n8n-nodes-langchain.lmChatAnthropic
Basic LLM Chain
@n8n/n8n-nodes-langchain.chainLlm
Gmail
n8n-nodes-base.gmail
Google Sheets
n8n-nodes-base.googleSheets
HTTP Request
n8n-nodes-base.httpRequest
Slack
n8n-nodes-base.slack