Personalized B2B Cold Email Sequence with GPT-4 + Gmail Auto-Reply Detection

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Built by Peyrichou Maxime Peyrichou Maxime
Created on June 15, 2026

Description

🎯 Automated B2B Cold Email Sequence with AI Personalization

Stop manually sending follow-ups. This workflow automates your entire cold email outreach with AI-powered personalization, smart scheduling, and automatic reply detection.

✨ What It Does

This workflow sends a perfectly-timed 3-email sequence to B2B prospects with:

AI-generated personalized emails** adapted to each prospect's sector, company size, and role
Smart scheduling**: Only sends Tuesday/Wednesday/Thursday at optimal times (~9AM with randomization)
Bilingual support**: Auto-detects French or English prospects
Reply detection**: Automatically stops the sequence when someone replies
Spam prevention**: Randomized sending times, professional intervals
Full tracking**: Updates Google Sheets with send status and reply detection
Slack notifications**: Get alerted immediately when a hot lead responds

📊 Expected Results

Based on real usage:
10-15% reply rate** (vs 3-8% for generic cold emails)
2-5 hot leads** per 30 prospects contacted
90% time saved** vs manual outreach
Professional delivery** that preserves sender reputation

🎬 How It Works

Add prospect to Google Sheet (Email, Name, Company, etc.)
Workflow triggers automatically on new row
Time planning calculates optimal send dates (Tue/Wed/Thu only)
Email 1 (J0): AI generates introduction with value prop (80-120 words)
Wait 3 days
Email 2 (J+3): Follow-up with new angle or case study (70-90 words)
Wait 4 days
Email 3 (J+7): Final soft close, respectful exit (60-100 words)
Reply detection: Monitors Gmail → marks prospect "hot" → Slack alert → stops sequence

🚀 Perfect For

Sales teams doing B2B cold outreach
Agencies prospecting new clients
SaaS founders building their pipeline
Consultants/freelancers doing business development
Anyone tired of manual follow-ups and low response rates

⚙️ Requirements

Required:
Google Sheets (free)
Gmail account (free)
OpenAI API key (~$0.50 per 100 emails)

Optional:
Slack (for notifications)

n8n version: Compatible with n8n 1.0+


Nodes Used (5)

AI Agent
@n8n/n8n-nodes-langchain.agent
Code
n8n-nodes-base.code
Google Sheets
n8n-nodes-base.googleSheets
OpenAI Chat Model
@n8n/n8n-nodes-langchain.lmChatOpenAi
Slack
n8n-nodes-base.slack